Membrane Insertion Potential of Synthetic Cell Penetrating Peptides
نویسندگان
چکیده
منابع مشابه
Secondary structure of cell-penetrating peptides controls membrane interaction and insertion.
The clinical use of efficient therapeutic agents is often limited by the poor permeability of the biological membranes. In order to enhance their cell delivery, short amphipathic peptides called cell-penetrating peptides (CPPs) have been intensively developed for the last two decades. CPPs are based either on protein transduction domains, model peptide or chimeric constructs and have been used ...
متن کاملCell Penetrating Peptides
During the last ten years it has been observed that a number of peptides and proteins are able to penetrate the cell membrane and enter the cell. Furthermore, it has been shown that even many cargo molecules that are covalently attached to these peptides will be translocated into the cell. Peptides that show the ability to translocate through the cell membrane are usually short peptides of less...
متن کاملArginine-rich cell-penetrating peptides.
Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct transloc...
متن کاملIdentification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides.
Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides also have promise in drug design because of their exceptional stability, but to date only one cyclic peptide has been reported to penetrate cells, the Momordica cochinchinensis trypsin inhibitor II (MCoTI-II). M...
متن کاملCPPpred: prediction of cell penetrating peptides
Cell penetrating peptides (CPPs) are attracting much attention as a means of overcoming the inherently poor cellular uptake of various bioactive molecules. Here, we introduce CPPpred, a web server for the prediction of CPPs using a N-to-1 neural network. The server takes one or more peptide sequences, between 5 and 30 amino acids in length, as input and returns a prediction of how likely each p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.607